Each gate has six lines, and the background of an era carries the theme of one of them. Because the precession moves backward, it goes from the first line of Gate 37 straight into the sixth line of Gate 55. First lines are about foundations and investigation. Ra said "The great global theme is going to begin with selfishness." He meant dedication to your own process, not being mean. He said people with a 6 in their profile will feel more at home in it. It is the mood of an era, not a grade on anyone.
This is not a fact, not medical advice and not a promise of healing. It is part of the cosmology Ra Uru Hu, who founded Human Design, left behind, and nobody knows exactly how it will unfold.
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